What are the rules of investing in science-based innovation? How much long-term thinking does it take to get through tightened markets and economic downturns? These questions are at the core of Vicki L. Sato´s research, who is a Professor of Management Practice in the Technology and Operations Management unit at Harvard Business School. In addition, she is also an advisor to Atlas Venture´s life sciences team.

In her view, smart science-based businesses regard today´s economic difficulties as an opportunity to boost their research and innovation for long-term competitive advantage. However, she cautions, different situations require different business decisions and investing in R&D is not always the key to success. The right approach, Sato argues, is to evaluate innovation management challenges from various  perspectives, such as corporate strategy, organizational design, decision-making, and resource allocation. This is even more important as key investment metrics, which are  measuring a company´s past and current financial performance, will not suffice as a stand-alone parameter in determining future success. Even though this is not a new observation and Sato admits that “the rules haven´t been written yet in this field of study”, the faculty research focuses on best practices and cases studies and may therefore come up with insightful and valuable concepts on investing in science-based businesses. We are looking forward to any future updates!  » Read more...

“Start-up Nation” by Dan Senor and Saul Singer addresses the trillion-dollar question: How is it that a country of a mere 7.1 million people has per capita venture capital investments 2.5 times greater than in the US (more than 30 times greater than in Europe), the highest density of high tech start-ups in the world (1 for every 1,844 inhabitant) and more companies listed at NASDAQ than all companies from the entire European continent?

The book is about Israel, and while much can be attributed to the extraordinary history of the country and its hostile environment, other factors such as a culture of leadership, risk management and  ”can do” attitude are at least equally important . “When an Israeli entrepreneur has a business idea,” the authors state, “he will start it that week.”

The book points out that while clusters of excellence with tight proximity to great universities, large corporations and start-ups (as well as to suppliers, an engineering talent pool and venture capital) are important, this is not enough. In Israel, a typical high tech start-up receives about 10 times more seed funding than in Europe although the turnover rate of start-ups is much shorter and faster, even compared to US standards. In addition, as compared to Korea, Singapore, China and even to the EU and US, the country has a culture of constantly challenging authorities and wide-held beliefs and of team orientation and networking.  » Read more...

MediGene AG (Frankfurt, Prime Standard, MDG, TecDAX) has announced the sale of full European marketing and distribution rights to Eligard^® (leuprolide acetate, for the treatment of hormone-dependent prostate cancer) to Astellas Pharma Europe Ltd. (London, “Astellas”), previously MediGene’s European marketing partner for Eligard^®. Astellas will make one-off payments totalling EUR 25 million, while MediGene remains entitled to royalties. There will be no further costs to MediGene. The sales price reflects the full NPV of all future Eligard® revenues while allowing MediGene to benefit from continued Eligard® growth. For more information, please see the full press release.

In several clinical trials, antibody company Micromet has demonstrated outstanding efficacy and safety of its bispecific BiTE antibodies which come with two binding sites: one for a cancer target and a second one for a T cell. As a result, T cells are recruited and guided directly to the tumor cell, initiating cancer cell death in a serial fashion.

In this week’s PNAS, researchers of the company demonstrate that the BiTE antibodies also can overcome the notorious resistance against conventional monoclonal antibodies arising in many cancer patients.

The researchers converted the anti-EGFR antibodies cetuximab (Erbitux) and panitumumab (Vectibix) into BiTE antibodies by adding the binding site for T cells. In animal models, these BiTE antibodies then showed a remarkably high potency (in the sub-picomolar range) against cancer cells with KRAS and BRAF-mutations which made them resistant to the original monoclonal antibodies.  » Read more...