- Nanomedicine and Medical Education leaders are joining their forces in the United States to accelerate the development of NanoXray -

Nanobiotix, a company developing novel cancer nanotherapeutics and Thomas Jefferson University, one of Philadelphia’s premier medical and health sciences universities, today announced that they have entered into a research collaboration to accelerate the development of Nanobiotix’ lead compound NBTXR3 in the US.

Under the terms of the collaboration agreement, Nanobiotix will fund a 2-year preclinical research program, which will be directed by Bo Lu, MD, Professor in the Department of Radiation Oncology at Jefferson and Director of the department’s Division of Molecular Radiation Biology. The goal of the program is to study the therapeutic efficacy of NBTXR3, the lead product of Nanobiotix´ NanoXray pipeline.  » Read more...

French nanomedicine company Nanobiotix is featured in a one-page article by Susanne Kutter in this week’s Wirtschaftswoche. The article (not yet online) features the technology by Nanobiotix and its NBTXR3 compound which has been developed to enhance the local destruction of tumor mass during radiotherapy.

NBTXR3 is a nanoparticle consisting of hafnium oxide crystals. Once injected into the tumor, NBTXR3 accumulates in the cancer cells. Due to the physical properties of hafnium oxide, the particles emit huge amounts of electrons upon radiation. This leads to the formation of radicals within the tumor cell, which in turn damage the cancer cells and cause their targeted destruction. NBTXR3 particles are inert and emit electrons only during their exposure to radiotherapy. As a result, the destructive power of standard radiation therapy could be locally and selectively enhanced within the tumor cells.  » Read more...

- A Completely New Cancer Treatment to Be Tested in Patients with Soft Tissue Sarcoma -

Nanobiotix, a company developing novel cancer nanotherapeutics, announced today that its lead compound NBTXR3 has received the formal authorization from the French Medicine Agency, AFSSAPS[1], to start the first clinical trial[2].

27 patients diagnosed with soft tissue sarcoma will be enrolled in the Phase I study and will receive NBTXR3 as an intra-tumoral injection with radiotherapy prior to surgery (first-line treatment) (www.clinicaltrial.gov). The primary endpoints of the clinical trial are the feasibility of NBTXR3 administration and safety. Preliminary data are expected by the end of 2012.  » Read more...